Dr. Dorleta Otaegui

Dorleta Otaegui obtained her Bachelor’s Degree in Pharmacy in 2004 from the University of the Basque Country (UPV/EHU), acquiring a strong foundation in pharmacology, chemistry, and biology applied to the pharmaceutical industry. She subsequently pursued a Ph.D. in Organic Chemistry at the same institution, which she completed in 2009. Her doctoral research integrated computational chemistry and experimental approaches. She applied molecular modeling techniques to predict the interactions between inhibitors and histone deacetylases (HDACs), followed by the synthesis of these compounds in the laboratory. The synthesized molecules were evaluated through biological assays to determine their inhibitory activity against HDAC enzymes. In addition, pharmacokinetic studies were conducted on the most promising candidates to assess their potential as therapeutic agents. In 2015, she obtained Certification in Experimental Animal Techniques, in compliance with ethical and legal standards for biomedical research. Dorleta Otaegui has extensive experience in the synthesis and characterization of bioactive compounds, with particular expertise in drug development, mass spectrometry, and preclinical research. Her scientific work includes the design of novel compounds with potential anticancer activity, as well as the optimization of biotechnological processes for viral vector production. She has developed strong technical expertise in a wide range of analytical techniques, including: Mass spectrometry (ESI-TOF, MALDI-TOF) for structural characterization of new chemical entities ICP-MS and UPLC-ESI-MS for quantitative analysis of biological and material samples Dynamic light scattering (DLS) FPLC protein purification systems Throughout her career, she has been actively involved in preclinical research, particularly in oncology. She has coordinated studies related to pharmacokinetics, formulation, and stability of novel compounds, and has contributed to the development of analytical methods to support drug development processes, from synthesis through to preclinical evaluation.

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