Ana Beloqui Elizazu
Research Staff
Coordinator
Proteina-polimero biohibridoak
Polimeroak osasunerako
Dr. Ana Beloqui leads the PolyZymes Lab at POLYMAT, where she investigates the chemistry at the interface of biomolecules and synthetic materials. Her career traces a path from classical biocatalysis to the design of advanced polymer–protein hybrids, building a research program that bridges chemistry, materials science, and biotechnology.
She trained as a chemist at the University of Navarra and completed her PhD at the Institute of Catalysis (ICP-CSIC/Universidad Autónoma de Madrid), focusing on the discovery and engineering of industrially relevant enzymes. Postdoctoral work took her across Europe: first to CICbiomaGUNE, to study interactions between biomacromolecules and (in)organic systems, then to the Karlsruhe Institute of Technology, where she developed methods to encapsulate single proteins within polymer networks. Returning to the Basque Country in 2016 through a Gipuzkoa Talent Attraction fellowship, she established her first independent research line at CICnanoGUNE. In 2020, she joined POLYMAT and the University of the Basque Country (UPV/EHU) as an Ikerbasque Fellow with a Ramón y Cajal contract, and now holds an Associate Professor position leading her own group.
Her research centers on stabilizing and enhancing functional proteins through polymer-based technologies. A defining contribution is the methodology she pioneered for encapsulating single enzymes in polymer nanogels (Small, 2016), since extended to antibodies and other sensitive biomolecules. Current interests include chemo-enzymatic nanoreactors built from polymer-protein hybrids, stimuli-responsive materials for catalysis and sensing, and nanogel platforms for gene delivery.
Her contributions have been recognized internationally, including the RSEQ "Young Group Leader Researcher" award, a Leonardo Grant from the BBVA Foundation, and coordination of the European doctoral network TheraTools-DN. She has secured substantial competitive national and international funding, authored publications in journals such as Nature, Angewandte Chemie, and PNAS, and holds several patent applications, reflecting a sustained commitment to translating fundamental research into real-world impact.
Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy
Kumar K., Gurol M., Sanjarnia P., Orellano M.S., Beloqui A., Ebo L., Picchio M.L. and Calderón M.
Microglia encapsulation in nanozyme-loaded hydrogels: response to oxidative stress and inflammation
Martín-Colomo S., Ontoria A., Tapeinos C., Beloqui A., Pineda J.R. and Larrañaga A.
Cetuximab-loaded self-assembled polymeric nanoparticles for the integrin-targeted therapy of glioblastoma
Mishra D., Calderón M., Beloqui A. and Sosnik A.
Multifunctional Protein Eutectogels Based on Polyphenolic: Zwitterionic Low-Transition-Temperature Mixtures
S. Martin-Saldana, A. de Leon, M. de la Mata, N. Politakos, J. Olmedo-Martinez, A.J. Müller, A. Beloqui, M. Calderon and M. Picchio
Compartmentalization of multilayer microreactors using protein-polymer hybrids
I. Alonso-Sampedro, A. Larrañaga and A. Beloqui
Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier
E. Romero-Ben, U. Goswami, J. Soto-Cruz, A. Mansoori-Kermani, D. Mishra, S. Martin-Saldaña, J. Muñoz-Ugartemendia, A. Sosnik, M. Calderón, A. Beloqui and A. Larrañaga
Polypeptide-based multilayer capsules with anti-inflammatory properties: exploring different strategies to incorporate hydrophobic drugs
M. Motta, S. Martin-Saldaña, A. Beloqui, M. Calderón and A. Larrañaga
Immobilization of Enzyme–Polymer Hybrids and Nanozymes Through Electrostatic Interactions: Toward Multicatalytic Microreactors with Controlled Nanoarchitecture
A. Ontoria, I. Alonso-Sampedro, Y. Yan, A. Latif, B. Spencer, A. Larrañaga, A. Beloqui and C. Tapeinos
Enzyme-Polymer Hybrids for Chemoenzymatic Catalysis
K. Kumar, A. Ontoria and A. Beloqui
Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis
M. Martínez-Cartagena, L. Suarez, A. Ontoria, F. Benítez, E. Rezabal, M. Orellano, M. Calderón, C. Huck-Iriart, A. Picco, M. Picchio and A. Beloqui
Travelling in Time with Proteins: Directed Evolution vs. Ancestral Reconstruction
A. Manteca, L. Teixeira, E. Lopez-Martinez, L. Garcia, R. Lopez-Domene, A. Beloqui, N. Ferruz, A. Innis, J. Baret and A. Cortajarena
Drug delivery <i>via</i> a 3D electro-swellable conjugated polymer hydrogel
I. Aziz, J. Gladisch, S. Griggs, M. Moser, H. Biesmans, A. Beloqui, I. McCulloch, M. Berggren and E. Stavrinidou
Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
M. Picchio, M. Orellano, M. Motta, C. Huck-Iriart, D. Sánchez-deAlcázar, R. López-Domene, B. Martín-García, A. Larrañaga, A. Beloqui, D. Mecerreyes and M. Calderón
Engineered Metal-Loaded Biohybrids to Promote the Attachment and Electron-Shuttling between Enzymes and Carbon Electrodes
A. Rodriguez-Abetxuko, E. Romero-Ben, A. Ontoria, M. Heredero, B. Martín-García, K. Kumar, S. Martín-Saldaña, F. Conzuelo and A. Beloqui
Eutectogels as Promising Materials in Biocatalysis
K. Kumar, M. Calderón, A. Beloqui and M. Picchio
“Green” synthesized versus chemically synthesized zinc oxide nanoparticles: In vivo antihyperglycemic activity and pharmacokinetics
E. Kambale, I. Domingues, W. Zhang, V. Marotti, C. Chen, K. Hughes, J. Quetin-Leclercq, P. Memvanga and A. Beloqui
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
V. Marotti, Y. Xu, C. Bohns Michalowski, W. Zhang, I. Domingues, H. Ameraoui, T. Moreels, P. Baatsen, M. Van Hul, G. Muccioli, P. Cani, M. Alhouayek, A. Malfanti and A. Beloqui
Enzymatic Degradation Behavior of Self-Degradable Lipase-Embedded Aliphatic and Aromatic Polyesters and Their Blends
M. Peñas, A. Beloqui, A. Martínez de Ilarduya, S. Suttiruengwong, R. Hernández and A.J. Müller
Materials Containing Single-, Di-, Tri-, and Multi-Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications
J. Tiwari, K. Kumar, M. Safarkhani, M. Umer, A. Vilian, A. Beloqui, G. Bhaskaran, Y. Huh and Y. Han
Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery
J. Udabe, S. Martin-Saldaña, Y. Tao, M. Picchio, A. Beloqui, A. Paredes and M. Calderón
Hybrid Nanogel-Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
D. Esporrín-Ubieto, C. Huck-Iriart, A. Picco, A. Beloqui and M. Calderón
Eutectogels: The Multifaceted Soft Ionic Materials of Tomorrow
P. Mercadal, A. González, A. Beloqui, L. Tomé, D. Mecerreyes, M. Calderón and M. Picchio
Enzyme-Polymer Conjugates for Tuning, Enhancing, and Expanding Biocatalytic Activity
M. Heredero and A. Beloqui
An Emerging Nanozyme Class for à la carte Enzymatic-Like Activities based on Protein-Metal Nanocluster Hybrids
R. López-Domene, S. Vázquez-Díaz, E. Modin, A. Beloqui and A. Cortajarena
Nanozymes with versatile redox capabilities inspired in metalloenzymes
R. López-Domene, K. Kumar, J. Barcelon, G. Guedes, A. Beloqui and A. Cortajarena
In vitro Production of Hemin-Based Artificial Metalloenzymes
R. López-Domene, A. Manteca, A. Rodriguez-Abetxuko, A. Beloqui and A. Cortajarena
Exploiting the biological effect exerted by lipid nanocapsules in non-alcoholic fatty liver disease
I. Domingues, C. Michalowski, V. Marotti, W. Zhang, M. Van Hul, P. Cani, I. Leclercq and A. Beloqui
Ana Beloqui
A. Beloqui
Metal-Organic Enzyme Nanogels as Nanointegrated Self-Reporting Chemobiosensors
D. Sanchez-deAlcazar, A. Rodriguez-Abetxuko and A. Beloqui
Recent advances and future perspectives of porous materials for biomedical applications
M. Orellano, O. Sanz, S. Camarero-Espinosa, A. Beloqui and M. Calderon
A Versatile Chemoenzymatic Nanoreactor that Mimics NAD(P)H Oxidase for the In Situ Regeneration of Cofactors
A. Rodriguez-Abetxuko, A. Reifs, D. Sanchez-deAlcazar and A. Beloqui
Tunable Polymeric Scaffolds for Enzyme Immobilization
A. Rodriguez-Abetxuko, D. Sanchez-deAlcazar, P. Munumer and A. Beloqui
Protein-based functional hybrid bionanomaterials by bottom-up approaches
A. Beloqui and A. Cortajarena
Nanoconfined (Bio)Catalysts as Efficient Glucose-Responsive Nanoreactors
A. Rodriguez-Abetxuko, P. Muñumer, M. Okuda, J. Calvo, M. Knez and A. Beloqui


