Dr. Maria Angela Motta
Maria Angela Motta obtained her B.Sc. and M.Sc. degrees in Chemistry from the Department of Chemical Sciences at the University of Padua (Italy) in 2014 and 2017, respectively, under the supervision of Prof. Alessandro Moretto. During this period, she developed expertise in the synthesis and characterization of peptides and peptide-based polymers, contributing to the field through a publication in Peptide Science.
Before starting her doctoral studies, she worked as a Chemical Analyst at Mérieux NutriSciences (2018–2019), where she gained experience in pharmaceutical analysis, regulatory compliance, and analytical method validation using advanced techniques, including ICP-OES and ICP-MS.
In July 2025, Maria Angela was awarded a Ph.D. with Honors and International Mention in Applied Chemistry and Polymeric Materials from the University of the Basque Country (UPV/EHU). Under the supervision of Prof. Marcelo Calderón and Prof. Aitor Larrañaga, her research encompassed polymer chemistry, drug delivery, nanomaterials, and biomedicine. Her doctoral thesis focused on the fabrication of multilayer polypeptide capsules on micro- and nano-meter scale using layer-by-layer (LbL) assembly, with applications in wound healing, bioreactors, and drug delivery. During her Ph.D., she authored and co-authored peer-reviewed publications in leading international journals, including Advanced Functional Materials, Journal of Materials Chemistry B, Carbohydrate Polymers, and Advances in Colloid and Interface Science.
In 2024, she completed a three-month research stay as a visiting Ph.D. researcher at the Clinical Research Center for Hair and Skin Science, Charité – Universitätsmedizin Berlin (Germany), under the supervision of Dr. Fiorenza Rancan. Her work focused on the topical application of nanoparticles to ex vivo human wound models to investigate their wound healing potential.
Maria Angela is currently a Postdoctoral Researcher at POLYMAT, where she develops hydrogel- and film-based biomaterials for wound care and other biomedical applications, with a strong emphasis on technology transfer and translational research.
Publicaciones
Surface functionalization of multilayer nanoparticles with hyaluronic acid or alternative polymers: Effects on cellular uptake and re-epithelialization in a human ex vivo wound model
M. Motta, U. Semenko, U. Goswami, Z. Zhao, F. Rancan, A. Larranaga and M. Calderdon
Polypeptide-based multilayer capsules with anti-inflammatory properties: exploring different strategies to incorporate hydrophobic drugs
M. Motta, S. Martin-Saldaña, A. Beloqui, M. Calderón and A. Larrañaga
Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
M. Picchio, M. Orellano, M. Motta, C. Huck-Iriart, D. Sánchez-deAlcázar, R. López-Domene, B. Martín-García, A. Larrañaga, A. Beloqui, D. Mecerreyes and M. Calderón
Polypeptide-based multilayer nanoarchitectures: Controlled assembly on planar and colloidal substrates for biomedical applications
M. Motta, L. Mulko, E. Marin, A. Larrañaga and M. Calderón


