Ana Beloqui Elizazu


Research Staff

Coordinator

Híbridos multifuncionales de proteínas y polímeros

Polímeros para la salud

+34943018838

ana.beloquie@ehu.eus



Dr. Ana Beloqui leads the PolyZymes Lab at POLYMAT, where she investigates the chemistry at the interface of biomolecules and synthetic materials. Her career traces a path from classical biocatalysis to the design of advanced polymer–protein hybrids, building a research program that bridges chemistry, materials science, and biotechnology. She trained as a chemist at the University of Navarra and completed her PhD at the Institute of Catalysis (ICP-CSIC/Universidad Autónoma de Madrid), focusing on the discovery and engineering of industrially relevant enzymes. Postdoctoral work took her across Europe: first to CICbiomaGUNE, to study interactions between biomacromolecules and (in)organic systems, then to the Karlsruhe Institute of Technology, where she developed methods to encapsulate single proteins within polymer networks. Returning to the Basque Country in 2016 through a Gipuzkoa Talent Attraction fellowship, she established her first independent research line at CICnanoGUNE. In 2020, she joined POLYMAT and the University of the Basque Country (UPV/EHU) as an Ikerbasque Fellow with a Ramón y Cajal contract, and now holds an Associate Professor position leading her own group. Her research centers on stabilizing and enhancing functional proteins through polymer-based technologies. A defining contribution is the methodology she pioneered for encapsulating single enzymes in polymer nanogels (Small, 2016), since extended to antibodies and other sensitive biomolecules. Current interests include chemo-enzymatic nanoreactors built from polymer-protein hybrids, stimuli-responsive materials for catalysis and sensing, and nanogel platforms for gene delivery. Her contributions have been recognized internationally, including the RSEQ "Young Group Leader Researcher" award, a Leonardo Grant from the BBVA Foundation, and coordination of the European doctoral network TheraTools-DN. She has secured substantial competitive national and international funding, authored publications in journals such as Nature, Angewandte Chemie, and PNAS, and holds several patent applications, reflecting a sustained commitment to translating fundamental research into real-world impact.

Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy
Kumar K., Gurol M., Sanjarnia P., Orellano M.S., Beloqui A., Ebo L., Picchio M.L. and Calderón M.
NANO LETTERS Vol. 26, Núm. 17, pp. 5747–5756 10.1021/acs.nanolett.6c00338 01/01/2026
Microglia encapsulation in nanozyme-loaded hydrogels: response to oxidative stress and inflammation
Martín-Colomo S., Ontoria A., Tapeinos C., Beloqui A., Pineda J.R. and Larrañaga A.
Nanomedicine Vol. 21, Núm. 10, pp. 1437–1457 10.1080/17435889.2026.2667955 01/01/2026
Cetuximab-loaded self-assembled polymeric nanoparticles for the integrin-targeted therapy of glioblastoma
Mishra D., Calderón M., Beloqui A. and Sosnik A.
JCIS Open Vol. 23 10.1016/j.jciso.2026.100201 01/01/2026
Multifunctional Protein Eutectogels Based on Polyphenolic: Zwitterionic Low-Transition-Temperature Mixtures
S. Martin-Saldana, A. de Leon, M. de la Mata, N. Politakos, J. Olmedo-Martinez, A.J. Müller, A. Beloqui, M. Calderon and M. Picchio
ADVANCED FUNCTIONAL MATERIALS Vol. 36, Núm. 9 10.1002/adfm.202514002 26/08/2025
Compartmentalization of multilayer microreactors using protein-polymer hybrids
I. Alonso-Sampedro, A. Larrañaga and A. Beloqui
POLYMER Vol. 323 10.1016/j.polymer.2025.128182 01/01/2025
Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier
E. Romero-Ben, U. Goswami, J. Soto-Cruz, A. Mansoori-Kermani, D. Mishra, S. Martin-Saldaña, J. Muñoz-Ugartemendia, A. Sosnik, M. Calderón, A. Beloqui and A. Larrañaga
Acta Biomaterialia Vol. 196, pp. 17–49 10.1016/j.actbio.2025.02.065 01/01/2025
Polypeptide-based multilayer capsules with anti-inflammatory properties: exploring different strategies to incorporate hydrophobic drugs
M. Motta, S. Martin-Saldaña, A. Beloqui, M. Calderón and A. Larrañaga
Journal of Materials Chemistry B Vol. 13, Núm. 18, pp. 5297–5314 10.1039/d4tb01906g 01/01/2025
Immobilization of Enzyme–Polymer Hybrids and Nanozymes Through Electrostatic Interactions: Toward Multicatalytic Microreactors with Controlled Nanoarchitecture
A. Ontoria, I. Alonso-Sampedro, Y. Yan, A. Latif, B. Spencer, A. Larrañaga, A. Beloqui and C. Tapeinos
Small Science Vol. 5, Núm. 8 10.1002/smsc.202500167 01/01/2025
Enzyme-Polymer Hybrids for Chemoenzymatic Catalysis
K. Kumar, A. Ontoria and A. Beloqui
Vol. 76, pp. 27–51 10.1007/3418_2025_125 01/01/2025
Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis
M. Martínez-Cartagena, L. Suarez, A. Ontoria, F. Benítez, E. Rezabal, M. Orellano, M. Calderón, C. Huck-Iriart, A. Picco, M. Picchio and A. Beloqui
ADVANCED MATERIALS Vol. 38, Núm. 51 10.1002/adma.202517014 01/01/2025
Travelling in Time with Proteins: Directed Evolution vs. Ancestral Reconstruction
A. Manteca, L. Teixeira, E. Lopez-Martinez, L. Garcia, R. Lopez-Domene, A. Beloqui, N. Ferruz, A. Innis, J. Baret and A. Cortajarena
PROTEIN SCIENCE Vol. 33, Núm. 1, pp. 210–210 001437110900374 01/12/2024
Drug delivery <i>via</i> a 3D electro-swellable conjugated polymer hydrogel
I. Aziz, J. Gladisch, S. Griggs, M. Moser, H. Biesmans, A. Beloqui, I. McCulloch, M. Berggren and E. Stavrinidou
Journal of Materials Chemistry B Vol. 12, Núm. 16, pp. 4029–4038 10.1039/d3tb02592f 26/03/2024
Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
M. Picchio, M. Orellano, M. Motta, C. Huck-Iriart, D. Sánchez-deAlcázar, R. López-Domene, B. Martín-García, A. Larrañaga, A. Beloqui, D. Mecerreyes and M. Calderón
ADVANCED FUNCTIONAL MATERIALS Vol. 34, Núm. 18 10.1002/adfm.202313747 01/01/2024
Engineered Metal-Loaded Biohybrids to Promote the Attachment and Electron-Shuttling between Enzymes and Carbon Electrodes
A. Rodriguez-Abetxuko, E. Romero-Ben, A. Ontoria, M. Heredero, B. Martín-García, K. Kumar, S. Martín-Saldaña, F. Conzuelo and A. Beloqui
ADVANCED FUNCTIONAL MATERIALS Vol. 34, Núm. 18 10.1002/adfm.202400479 01/01/2024
Eutectogels as Promising Materials in Biocatalysis
K. Kumar, M. Calderón, A. Beloqui and M. Picchio
ChemCatChem Vol. 16, Núm. 12 10.1002/cctc.202400204 01/01/2024
“Green” synthesized versus chemically synthesized zinc oxide nanoparticles: In vivo antihyperglycemic activity and pharmacokinetics
E. Kambale, I. Domingues, W. Zhang, V. Marotti, C. Chen, K. Hughes, J. Quetin-Leclercq, P. Memvanga and A. Beloqui
International Journal of Pharmaceutics Vol. 650 10.1016/j.ijpharm.2023.123701 01/01/2024
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
V. Marotti, Y. Xu, C. Bohns Michalowski, W. Zhang, I. Domingues, H. Ameraoui, T. Moreels, P. Baatsen, M. Van Hul, G. Muccioli, P. Cani, M. Alhouayek, A. Malfanti and A. Beloqui
Bioactive Materials Vol. 32, pp. 206–221 10.1016/j.bioactmat.2023.09.014 01/01/2024
Enzymatic Degradation Behavior of Self-Degradable Lipase-Embedded Aliphatic and Aromatic Polyesters and Their Blends
M. Peñas, A. Beloqui, A. Martínez de Ilarduya, S. Suttiruengwong, R. Hernández and A.J. Müller
BIOMACROMOLECULES Vol. 25, Núm. 7, pp. 4030–4045 10.1021/acs.biomac.4c00161 01/01/2024
Materials Containing Single-, Di-, Tri-, and Multi-Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications
J. Tiwari, K. Kumar, M. Safarkhani, M. Umer, A. Vilian, A. Beloqui, G. Bhaskaran, Y. Huh and Y. Han
Advanced Science Vol. 11, Núm. 33 10.1002/advs.202403197 01/01/2024
Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery
J. Udabe, S. Martin-Saldaña, Y. Tao, M. Picchio, A. Beloqui, A. Paredes and M. Calderón
ACS Applied Materials & Interfaces Vol. 16, Núm. 36, pp. 47124–47136 10.1021/acsami.4c07669 01/01/2024
Hybrid Nanogel-Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
D. Esporrín-Ubieto, C. Huck-Iriart, A. Picco, A. Beloqui and M. Calderón
Small Vol. 20, Núm. 48 10.1002/smll.202404097 01/01/2024
Eutectogels: The Multifaceted Soft Ionic Materials of Tomorrow
P. Mercadal, A. González, A. Beloqui, L. Tomé, D. Mecerreyes, M. Calderón and M. Picchio
JACS Au Vol. 4, Núm. 10, pp. 3744–3758 10.1021/jacsau.4c00677 01/01/2024
Enzyme-Polymer Conjugates for Tuning, Enhancing, and Expanding Biocatalytic Activity
M. Heredero and A. Beloqui
CHEMBIOCHEM Vol. 24, Núm. 4 10.1002/cbic.202200611 01/01/2023
An Emerging Nanozyme Class for à la carte Enzymatic-Like Activities based on Protein-Metal Nanocluster Hybrids
R. López-Domene, S. Vázquez-Díaz, E. Modin, A. Beloqui and A. Cortajarena
ADVANCED FUNCTIONAL MATERIALS Vol. 33, Núm. 37 10.1002/adfm.202301131 01/01/2023
Nanozymes with versatile redox capabilities inspired in metalloenzymes
R. López-Domene, K. Kumar, J. Barcelon, G. Guedes, A. Beloqui and A. Cortajarena
Nanoscale Vol. 15, Núm. 42, pp. 16959–16966 10.1039/d3nr03443g 01/01/2023
In vitro Production of Hemin-Based Artificial Metalloenzymes
R. López-Domene, A. Manteca, A. Rodriguez-Abetxuko, A. Beloqui and A. Cortajarena
CHEMISTRY-A EUROPEAN JOURNAL Vol. 30, Núm. 11 10.1002/chem.202303254 01/01/2023
Exploiting the biological effect exerted by lipid nanocapsules in non-alcoholic fatty liver disease
I. Domingues, C. Michalowski, V. Marotti, W. Zhang, M. Van Hul, P. Cani, I. Leclercq and A. Beloqui
JOURNAL OF CONTROLLED RELEASE Vol. 356, pp. 542–553 10.1016/j.jconrel.2023.03.012 01/01/2023
Ana Beloqui
A. Beloqui
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 61, Núm. 39 10.1002/anie.202210501 26/09/2022
Metal-Organic Enzyme Nanogels as Nanointegrated Self-Reporting Chemobiosensors
D. Sanchez-deAlcazar, A. Rodriguez-Abetxuko and A. Beloqui
ACS Applied Materials & Interfaces Vol. 14, Núm. 24, pp. 27589–27598 10.1021/acsami.2c04385 08/06/2022
Recent advances and future perspectives of porous materials for biomedical applications
M. Orellano, O. Sanz, S. Camarero-Espinosa, A. Beloqui and M. Calderon
Nanomedicine Vol. 17, Núm. 4, pp. 197–200 10.2217/nnm-2021-0436 01/01/2022
A Versatile Chemoenzymatic Nanoreactor that Mimics NAD(P)H Oxidase for the In Situ Regeneration of Cofactors
A. Rodriguez-Abetxuko, A. Reifs, D. Sanchez-deAlcazar and A. Beloqui
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 61, Núm. 39 10.1002/anie.202206926 01/01/2022
Tunable Polymeric Scaffolds for Enzyme Immobilization
A. Rodriguez-Abetxuko, D. Sanchez-deAlcazar, P. Munumer and A. Beloqui
Frontiers in Bioengineering and Biotechnology Vol. 8 10.3389/fbioe.2020.00830 30/07/2020
Protein-based functional hybrid bionanomaterials by bottom-up approaches
A. Beloqui and A. Cortajarena
CURRENT OPINION IN STRUCTURAL BIOLOGY Vol. 63, pp. 74–81 10.1016/j.sbi.2020.04.005 01/01/2020
Nanoconfined (Bio)Catalysts as Efficient Glucose-Responsive Nanoreactors
A. Rodriguez-Abetxuko, P. Muñumer, M. Okuda, J. Calvo, M. Knez and A. Beloqui
ADVANCED FUNCTIONAL MATERIALS Vol. 30, Núm. 35 10.1002/adfm.202002990 01/01/2020